Cape Palmas is a headland on the extreme southeast end of the coast of Liberia, Africa, at the extreme southwest corner of the northern half of the continent. The Cape itself consists of a small, rocky peninsula connected to the mainland by a sandy isthmus. Immediately to the west of the peninsula is the estuary of the Hoffman River. Approximately 21 km (15 mi) further along the coast to the east, the Cavalla River empties into the sea, marking the border between Liberia and the Côte d'Ivoire. It marks the western limit of the Gulf of Guinea, according to the International Hydrographic Organization (IHO).

Approached from the sea, there are several landmarks at the cape. Offshore from the estuary of the Hoffman lies the small, oblong shape of Russwurm Island, which was named after the first black governor of Maryland In Africa (later Republic of Maryland), John Brown Russwurm. This island is connected to the peninsula by a breakwater. There is also a lighthouse warning of the numerous shoals in the surrounding sea area. Clearly visible from offshore is a white building with an enormous golden orb on the roof, this being the masonic lodge hall located in the city of Harper, Liberia.